8GAU

Structure of human NDS.1 Fab and 1G01 Fab in complex with influenza virus neuraminidase from A/Indiana/10/2011 (H3N2v)

Summary for 8GAU

Entry DOI	10.2210/pdb8gau/pdb
EMDB information	29907 29908 29909
Descriptor	Vasodilator-stimulated phosphoprotein, Neuraminidase chimera, Fab NDS.1, heavy chain, Fab NDS.1, light chain, ... (6 entities in total)
Functional Keywords	neuraminidase, antibody, influenza, viral protein-immune system complex, viral protein/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	149633.28
Authors	Tsybovsky, Y.,Lederhofer, J.,Kwong, P.D.,Kanekiyo, M. (deposition date: 2023-02-23, release date: 2024-02-28, Last modification date: 2024-04-24)
Primary citation	Lederhofer, J.,Tsybovsky, Y.,Nguyen, L.,Raab, J.E.,Creanga, A.,Stephens, T.,Gillespie, R.A.,Syeda, H.Z.,Fisher, B.E.,Skertic, M.,Yap, C.,Schaub, A.J.,Rawi, R.,Kwong, P.D.,Graham, B.S.,McDermott, A.B.,Andrews, S.F.,King, N.P.,Kanekiyo, M. Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase. Immunity, 57:574-586.e7, 2024 Cited by PubMed: 38430907 DOI: 10.1016/j.immuni.2024.02.003 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation