8G9E
Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and 5-(PCF2P)-IP5, an analog of 5-IP7
Summary for 8G9E
Entry DOI | 10.2210/pdb8g9e/pdb |
Descriptor | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, {difluoro[(R)-hydroxy{[(1s,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}phosphoryl]methyl}phosphonic acid, ... (5 entities in total) |
Functional Keywords | transferase inositol diphosphoinositol pentakisphosphate kinase analog methylenebisphosphonate ppip5k atp-grasp pyrophosphate diphosphate, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38970.64 |
Authors | |
Primary citation | Hostachy, S.,Wang, H.,Zong, G.,Franke, K.,Riley, A.M.,Schmieder, P.,Potter, B.V.L.,Shears, S.B.,Fiedler, D. Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. Chemistry, 29:e202302426-e202302426, 2023 Cited by PubMed: 37773020DOI: 10.1002/chem.202302426 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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