8G9C
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- difluoromethylenebisphosphonate inositol pentakisphosphate (5-PCF2P-IP5), an analogue of 5-InsP7
Summary for 8G9C
Entry DOI | 10.2210/pdb8g9c/pdb |
Descriptor | Diphosphoinositol polyphosphate phosphohydrolase 1, {difluoro[(R)-hydroxy{[(1s,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}phosphoryl]methyl}phosphonic acid, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphatase, nudix, catalysis mechanism, substrate specificity, inositol, inositol pyrophosphate, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20458.12 |
Authors | |
Primary citation | Hostachy, S.,Wang, H.,Zong, G.,Franke, K.,Riley, A.M.,Schmieder, P.,Potter, B.V.L.,Shears, S.B.,Fiedler, D. Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs. Chemistry, 29:e202302426-e202302426, 2023 Cited by PubMed: 37773020DOI: 10.1002/chem.202302426 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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