8G9C

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- difluoromethylenebisphosphonate inositol pentakisphosphate (5-PCF2P-IP5), an analogue of 5-InsP7

8G9C の概要

• エントリーDOI: 10.2210/pdb8g9c/pdb
• 分子名称: Diphosphoinositol polyphosphate phosphohydrolase 1, {difluoro[(R)-hydroxy{[(1s,2R,3S,4S,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl]oxy}phosphoryl]methyl}phosphonic acid, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: phosphatase, nudix, catalysis mechanism, substrate specificity, inositol, inositol pyrophosphate, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20458.12

構造登録者

Zong, G.,Wang, H.,Shears, S. (登録日: 2023-02-21, 公開日: 2024-01-03)

• 主引用文献: Hostachy, S.,Wang, H.,Zong, G.,Franke, K.,Riley, A.M.,Schmieder, P.,Potter, B.V.L.,Shears, S.B.,Fiedler, D.; Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs.; Chemistry, 29:e202302426-e202302426, 2023; PubMed: 37773020; DOI: 10.1002/chem.202302426

実験手法

X-RAY DIFFRACTION (1.4 Å)