8G9B

Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction

8G9B の概要

• エントリーDOI: 10.2210/pdb8g9b/pdb
• EMDBエントリー: 29357 29482 29848 29863
• 分子名称: Inosine-5'-monophosphate dehydrogenase 2, GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: filament, dehydrogenase, cbs domain, bateman domain, purine biosynthesis, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 472237.00

構造登録者

O'Neill, A.G.,Kollman, J.M. (登録日: 2023-02-21, 公開日: 2023-04-19, 最終更新日: 2023-08-09)

• 主引用文献: O'Neill, A.G.,Burrell, A.L.,Zech, M.,Elpeleg, O.,Harel, T.,Edvardson, S.,Mor-Shaked, H.,Rippert, A.L.,Nomakuchi, T.,Izumi, K.,Kollman, J.M.; Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.; J.Biol.Chem., 299:105012-105012, 2023; PubMed: 37414152; DOI: 10.1016/j.jbc.2023.105012

実験手法

ELECTRON MICROSCOPY (3 Å)