8G9A
Crystal structure of a resurrected ancestor (AncRNase) of the pancreatic-type RNases 2 and 3 sub-families
Summary for 8G9A
Entry DOI | 10.2210/pdb8g9a/pdb |
Descriptor | a resurrected ancestor (AncRNase) of the pancreatic-type RNases 2 and 3 sub-families, SULFATE ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | ancestral sequence reconstruction, asr, eosinophil-derived neurotoxin, edn, rnase 2, eosinophil cationic protein, ecp, rnase 3, ribonuclease, hydrolase, transphosphorylase |
Biological source | synthetic construct |
Total number of polymer chains | 4 |
Total formula weight | 64746.69 |
Authors | Tran, T.T.Q.,Pham, N.T.H.,Calmettes, C.,Doucet, N. (deposition date: 2023-02-21, release date: 2024-02-28, Last modification date: 2024-10-09) |
Primary citation | Tran, T.T.Q.,Narayanan, C.,Loes, A.N.,Click, T.H.,Pham, N.T.H.,Letourneau, M.,Harms, M.J.,Calmettes, C.,Agarwal, P.K.,Doucet, N. Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases. J.Biol.Chem., 300:107280-107280, 2024 Cited by PubMed: 38588810DOI: 10.1016/j.jbc.2024.107280 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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