8G7V
Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-inter)
Summary for 8G7V
Entry DOI | 10.2210/pdb8g7v/pdb |
EMDB information | 29825 |
Descriptor | Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, p3dsRNA24a, ... (5 entities in total) |
Functional Keywords | ribonucleoprotein complex, rna sensor, rig-i like receptor, ubiquitination, e3 ligase, trim family, antiviral protein, transferase-hydrolase-rna complex, transferase/hydrolase/rna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 325178.67 |
Authors | Wang, W.,Pyle, A.M. (deposition date: 2023-02-17, release date: 2023-11-15, Last modification date: 2024-05-29) |
Primary citation | Wang, W.,Gotte, B.,Guo, R.,Pyle, A.M. The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization. Nat Commun, 14:7308-7308, 2023 Cited by PubMed: 37951994DOI: 10.1038/s41467-023-42982-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
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