8G7T

Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-end)

Summary for 8G7T

• Entry DOI: 10.2210/pdb8g7t/pdb
• EMDB information: 29823
• Descriptor: Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, p3dsRNA24a, ... (5 entities in total)
• Functional Keywords: ribonucleoprotein complex, rna sensor, rig-i like receptor, ubiquitination, e3 ligase, trim family, antiviral protein, transferase-hydrolase-rna complex, transferase/hydrolase/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 325178.67

Authors

Wang, W.,Pyle, A.M. (deposition date: 2023-02-17, release date: 2023-11-15, Last modification date: 2024-05-29)

• Primary citation: Wang, W.,Gotte, B.,Guo, R.,Pyle, A.M.; The E3 ligase Riplet promotes RIG-I signaling independent of RIG-I oligomerization.; Nat Commun, 14:7308-7308, 2023; PubMed: 37951994; DOI: 10.1038/s41467-023-42982-0

Experimental method

ELECTRON MICROSCOPY (3.2 Å)