8G5H
Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroid
This is a non-PDB format compatible entry.
Summary for 8G5H
Entry DOI | 10.2210/pdb8g5h/pdb |
EMDB information | 29743 |
Descriptor | Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... (14 entities in total) |
Functional Keywords | ligand-gated ion channel, cys-loop receptor, neurotransmitter receptor, membrane protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 7 |
Total formula weight | 337661.30 |
Authors | Sun, C.,Gouaux, E. (deposition date: 2023-02-13, release date: 2023-09-20, Last modification date: 2023-11-15) |
Primary citation | Sun, C.,Zhu, H.,Clark, S.,Gouaux, E. Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology. Nature, 622:195-201, 2023 Cited by PubMed: 37730991DOI: 10.1038/s41586-023-06556-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.89 Å) |
Structure validation
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