8G26

Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 8.5

Summary for 8G26

Entry DOI	10.2210/pdb8g26/pdb
Descriptor	Cathepsin-G, Neutrophil elastase, MAP domain-containing protein, ... (6 entities in total)
Functional Keywords	protease inhibitor, immune evasion, neutrophil, s. aureus, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Staphylococcus aureus subsp. aureus Mu50 More
Total number of polymer chains	3
Total formula weight	62485.63
Authors	Mishra, N.B.,Geisbrecht, B.V. (deposition date: 2023-02-03, release date: 2023-04-26, Last modification date: 2023-10-25)
Primary citation	Mishra, N.,Herdendorf, T.J.,Prakash, O.,Geisbrecht, B.V. Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2. J.Biol.Chem., 299:104878-104878, 2023 Cited by PubMed: 37269950 DOI: 10.1016/j.jbc.2023.104878 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation