8G20
Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz327
Summary for 8G20
Entry DOI | 10.2210/pdb8g20/pdb |
Descriptor | Hdac6 protein, 4-[(N-butylpentanamido)methyl]-N-hydroxybenzamide, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase, hydrolase/inhibitor |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 2 |
Total formula weight | 81981.59 |
Authors | |
Primary citation | Sinatra, L.,Vogelmann, A.,Friedrich, F.,Tararina, M.A.,Neuwirt, E.,Colcerasa, A.,Konig, P.,Toy, L.,Yesiloglu, T.Z.,Hilscher, S.,Gaitzsch, L.,Papenkordt, N.,Zhai, S.,Zhang, L.,Romier, C.,Einsle, O.,Sippl, W.,Schutkowski, M.,Gross, O.,Bendas, G.,Christianson, D.W.,Hansen, F.K.,Jung, M.,Schiedel, M. Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. J.Med.Chem., 66:14787-14814, 2023 Cited by PubMed: 37902787DOI: 10.1021/acs.jmedchem.3c01385 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.766 Å) |
Structure validation
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