8G1Z

Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz317

8G1Z の概要

• エントリーDOI: 10.2210/pdb8g1z/pdb
• 分子名称: Hdac6 protein, 4-(acetamidomethyl)-N-hydroxybenzamide, ZINC ION, ... (6 entities in total)
• 機能のキーワード: histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase, hydrolase/inhibitor
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40823.51

構造登録者

Tararina, M.A.,Christianson, D.W. (登録日: 2023-02-03, 公開日: 2023-12-13)

• 主引用文献: Sinatra, L.,Vogelmann, A.,Friedrich, F.,Tararina, M.A.,Neuwirt, E.,Colcerasa, A.,Konig, P.,Toy, L.,Yesiloglu, T.Z.,Hilscher, S.,Gaitzsch, L.,Papenkordt, N.,Zhai, S.,Zhang, L.,Romier, C.,Einsle, O.,Sippl, W.,Schutkowski, M.,Gross, O.,Bendas, G.,Christianson, D.W.,Hansen, F.K.,Jung, M.,Schiedel, M.; Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.; J.Med.Chem., 66:14787-14814, 2023; PubMed: 37902787; DOI: 10.1021/acs.jmedchem.3c01385

実験手法

X-RAY DIFFRACTION (1.87 Å)