8FYX
Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Summary for 8FYX
Entry DOI | 10.2210/pdb8fyx/pdb |
EMDB information | 29599 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | gpcr signaling complex, serotonin receptor, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 151928.68 |
Authors | Warren, A.L.,Zilberg, G.,Capper, M.J.,Wacker, D. (deposition date: 2023-01-26, release date: 2024-05-15, Last modification date: 2024-06-19) |
Primary citation | Warren, A.L.,Lankri, D.,Cunningham, M.J.,Serrano, I.C.,Parise, L.F.,Kruegel, A.C.,Duggan, P.,Zilberg, G.,Capper, M.J.,Havel, V.,Russo, S.J.,Sames, D.,Wacker, D. Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Nature, 630:237-246, 2024 Cited by PubMed: 38720072DOI: 10.1038/s41586-024-07403-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.62 Å) |
Structure validation
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