8FY8

5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex

8FY8 の概要

• エントリーDOI: 10.2210/pdb8fy8/pdb
• EMDBエントリー: 29560
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: gpcr signaling complex, serotonin receptor, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151761.47

構造登録者

Warren, A.L.,Zilberg, G.,Capper, M.J.,Wacker, D. (登録日: 2023-01-25, 公開日: 2024-05-15, 最終更新日: 2024-06-19)

• 主引用文献: Warren, A.L.,Lankri, D.,Cunningham, M.J.,Serrano, I.C.,Parise, L.F.,Kruegel, A.C.,Duggan, P.,Zilberg, G.,Capper, M.J.,Havel, V.,Russo, S.J.,Sames, D.,Wacker, D.; Structural pharmacology and therapeutic potential of 5-methoxytryptamines.; Nature, 630:237-246, 2024; PubMed: 38720072; DOI: 10.1038/s41586-024-07403-2

実験手法

ELECTRON MICROSCOPY (2.79 Å)