8FX3

Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-GP, showing the structure of the complete active site in its open conformation

8FX3 の概要

• エントリーDOI: 10.2210/pdb8fx3/pdb
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER (3 entities in total)
• 機能のキーワード: hypoxanthine-guanine-xanthine phosphoribosyltransferase, inhibitor, hgxprt, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Trypanosoma cruzi (strain CL Brener)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52488.46

構造登録者

Hughes, R.,Meneely, K.M.,Glockzin, K.,Suthagar, K.,Tyler, P.C.,Lamb, A.L.,Meek, T.D.,Katzfuss, A. (登録日: 2023-01-23, 公開日: 2023-07-19, 最終更新日: 2023-11-22)

• 主引用文献: Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A.; Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.; Biochemistry, 62:2182-2201, 2023; PubMed: 37418678; DOI: 10.1021/acs.biochem.3c00116

実験手法

X-RAY DIFFRACTION (1.31 Å)