8FX3
Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Immucillin-GP, showing the structure of the complete active site in its open conformation
8FX3 の概要
エントリーDOI | 10.2210/pdb8fx3/pdb |
分子名称 | Hypoxanthine-guanine phosphoribosyltransferase, PHOSPHORIC ACID MONO-[5-(2-AMINO-4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-3,4-DIHYDROXY-PYRROLIDIN-2-YLMETHYL] ESTER (3 entities in total) |
機能のキーワード | hypoxanthine-guanine-xanthine phosphoribosyltransferase, inhibitor, hgxprt, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Trypanosoma cruzi (strain CL Brener) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 52488.46 |
構造登録者 | Hughes, R.,Meneely, K.M.,Glockzin, K.,Suthagar, K.,Tyler, P.C.,Lamb, A.L.,Meek, T.D.,Katzfuss, A. (登録日: 2023-01-23, 公開日: 2023-07-19, 最終更新日: 2023-11-22) |
主引用文献 | Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry, 62:2182-2201, 2023 Cited by PubMed: 37418678DOI: 10.1021/acs.biochem.3c00116 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.31 Å) |
構造検証レポート
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