8FWZ
Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Hydroxypropyl-Lin-ImmH Phosphonate
Summary for 8FWZ
Entry DOI | 10.2210/pdb8fwz/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, [(2R)-2-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl]phosphonic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | hypoxanthine-guanine-xanthine phosphoribosyltransferase, inhibitor, hgxprt, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Trypanosoma cruzi (strain CL Brener) |
Total number of polymer chains | 2 |
Total formula weight | 52465.38 |
Authors | Hughes, R.,Meneely, K.M.,Glockzin, K.,Clinch, K.,Tyler, P.C.,Lamb, A.L.,Meek, T.D.,Katzfuss, A. (deposition date: 2023-01-23, release date: 2023-07-19, Last modification date: 2023-11-22) |
Primary citation | Glockzin, K.,Meneely, K.M.,Hughes, R.,Maatouk, S.W.,Pina, G.E.,Suthagar, K.,Clinch, K.,Buckler, J.N.,Lamb, A.L.,Tyler, P.C.,Meek, T.D.,Katzfuss, A. Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors. Biochemistry, 62:2182-2201, 2023 Cited by PubMed: 37418678DOI: 10.1021/acs.biochem.3c00116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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