8FWU

Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX

8FWU の概要

• エントリーDOI: 10.2210/pdb8fwu/pdb
• EMDBエントリー: 29519
• 分子名称: Glutamate receptor ionotropic, kainate 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: iglur, kainate receptor, positive allosteric modulator, dnqx, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 428062.91

構造登録者

Yen, L.Y.,Gangwar, S.P.,Yelshanskaya, M.V.,Sobolevsky, A.I. (登録日: 2023-01-23, 公開日: 2023-04-19)

• 主引用文献: Gangwar, S.P.,Yen, L.Y.,Yelshanskaya, M.V.,Sobolevsky, A.I.; Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel.; Cell Rep, 42:112124-112124, 2023; PubMed: 36857176; DOI: 10.1016/j.celrep.2023.112124

実験手法

ELECTRON MICROSCOPY (3.18 Å)