8FWH
Crystal structure of bivalent antibody Fab fragment of Anti-human LAG3 (22D2)
This is a non-PDB format compatible entry.
Summary for 8FWH
Entry DOI | 10.2210/pdb8fwh/pdb |
Descriptor | Anti-human LAG3 (22D2) heavy chain, Anti-human LAG3 (22D2) light chain, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | fab, inhibitory receptors, immune system |
Biological source | Mus musculus (mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 47711.00 |
Authors | Mishra, A.K.,Agnihotri, P.,Mariuzza, R.A. (deposition date: 2023-01-22, release date: 2023-09-06, Last modification date: 2023-10-18) |
Primary citation | Mishra, A.K.,Shahid, S.,Karade, S.S.,Agnihotri, P.,Kolesnikov, A.,Hasan, S.S.,Mariuzza, R.A. CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure, 31:1149-, 2023 Cited by PubMed: 37619561DOI: 10.1016/j.str.2023.07.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.833 Å) |
Structure validation
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