8FWH

Crystal structure of bivalent antibody Fab fragment of Anti-human LAG3 (22D2)

This is a non-PDB format compatible entry.

Summary for 8FWH

• Entry DOI: 10.2210/pdb8fwh/pdb
• Descriptor: Anti-human LAG3 (22D2) heavy chain, Anti-human LAG3 (22D2) light chain, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: fab, inhibitory receptors, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 47711.00

Authors

Mishra, A.K.,Agnihotri, P.,Mariuzza, R.A. (deposition date: 2023-01-22, release date: 2023-09-06, Last modification date: 2023-10-18)

• Primary citation: Mishra, A.K.,Shahid, S.,Karade, S.S.,Agnihotri, P.,Kolesnikov, A.,Hasan, S.S.,Mariuzza, R.A.; CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker.; Structure, 31:1149-, 2023; PubMed: 37619561; DOI: 10.1016/j.str.2023.07.013

Experimental method

X-RAY DIFFRACTION (2.833 Å)