8FV4
EGFR(T790M/V948R) in complex with compound 2 (LN5993)
Summary for 8FV4
Entry DOI | 10.2210/pdb8fv4/pdb |
Descriptor | Epidermal growth factor receptor, N-{(3P)-3-[(4P)-4-(2-acetamidopyridin-4-yl)-2-(methylsulfanyl)-1H-imidazol-5-yl]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-9-carboxamide, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 151554.11 |
Authors | Ogboo, B.C.,Beyett, T.S.,Eck, M.J.,Heppner, D.E. (deposition date: 2023-01-18, release date: 2024-01-17, Last modification date: 2024-03-20) |
Primary citation | Wittlinger, F.,Ogboo, B.C.,Shevchenko, E.,Damghani, T.,Pham, C.D.,Schaeffner, I.K.,Oligny, B.T.,Chitnis, S.P.,Beyett, T.S.,Rasch, A.,Buckley, B.,Urul, D.A.,Shaurova, T.,May, E.W.,Schaefer, E.M.,Eck, M.J.,Hershberger, P.A.,Poso, A.,Laufer, S.A.,Heppner, D.E. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem, 7:38-38, 2024 Cited by PubMed: 38378740DOI: 10.1038/s42004-024-01108-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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