8FV4

EGFR(T790M/V948R) in complex with compound 2 (LN5993)

8FV4 の概要

• エントリーDOI: 10.2210/pdb8fv4/pdb
• 分子名称: Epidermal growth factor receptor, N-{(3P)-3-[(4P)-4-(2-acetamidopyridin-4-yl)-2-(methylsulfanyl)-1H-imidazol-5-yl]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-9-carboxamide, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151554.11

構造登録者

Ogboo, B.C.,Beyett, T.S.,Eck, M.J.,Heppner, D.E. (登録日: 2023-01-18, 公開日: 2024-01-17, 最終更新日: 2024-03-20)

• 主引用文献: Wittlinger, F.,Ogboo, B.C.,Shevchenko, E.,Damghani, T.,Pham, C.D.,Schaeffner, I.K.,Oligny, B.T.,Chitnis, S.P.,Beyett, T.S.,Rasch, A.,Buckley, B.,Urul, D.A.,Shaurova, T.,May, E.W.,Schaefer, E.M.,Eck, M.J.,Hershberger, P.A.,Poso, A.,Laufer, S.A.,Heppner, D.E.; Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.; Commun Chem, 7:38-38, 2024; PubMed: 38378740; DOI: 10.1038/s42004-024-01108-3

実験手法

X-RAY DIFFRACTION (2.2 Å)