8FU6

GCGR-Gs complex in the presence of RAMP2

8FU6 の概要

• エントリーDOI: 10.2210/pdb8fu6/pdb
• EMDBエントリー: 29453
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: g-protein coupled receptor, ramp, g-protein, gs, nb35, gpcr, glucagon receptor, glucagon, peptide agonist, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 166540.70

構造登録者

Krishna Kumar, K.,O'Brien, E.S.,Wang, H.,Montabana, E.,Kobilka, B.K. (登録日: 2023-01-16, 公開日: 2023-04-12)

• 主引用文献: Krishna Kumar, K.,O'Brien, E.S.,Habrian, C.H.,Latorraca, N.R.,Wang, H.,Tuneew, I.,Montabana, E.,Marqusee, S.,Hilger, D.,Isacoff, E.Y.,Mathiesen, J.M.,Kobilka, B.K.; Negative allosteric modulation of the glucagon receptor by RAMP2.; Cell, 186:1465-1477.e18, 2023; PubMed: 37001505; DOI: 10.1016/j.cell.2023.02.028

実験手法

ELECTRON MICROSCOPY (2.9 Å)