8FRI

LSD1-CoREST in complex with AW4, short soaking

Summary for 8FRI

• Entry DOI: 10.2210/pdb8fri/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-4,6-dioxo-3-([1~1~,2~1~:2~3~,3~1~-terphenyl]-1~4~-yl)-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name) (3 entities in total)
• Functional Keywords: epigenetics, histone demethylase, drug resistance, covalent inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 112583.29

Authors

Caroli, J.,Mattevi, A. (deposition date: 2023-01-07, release date: 2024-08-07)

• Primary citation: Caroli, J.,Mattevi, A.; Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)