8FQ5

GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110)

8FQ5 の概要

• エントリーDOI: 10.2210/pdb8fq5/pdb
• EMDBエントリー: 29360 29378
• 分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: ionotropic glutamate receptors, ampa receptors, ligand gated ion channel, auxiliary subunit, tarp, stargazin, tarp gamma2, glutamate, calcium, neurotransmitter receptor, synaptic transmission, transport protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 546818.89

構造登録者

Nakagawa, T. (登録日: 2023-01-05, 公開日: 2024-02-28, 最終更新日: 2024-05-01)

• 主引用文献: Nakagawa, T.,Wang, X.T.,Miguez-Cabello, F.J.,Bowie, D.; The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport.; Nat.Struct.Mol.Biol., 31:688-700, 2024; PubMed: 38409505; DOI: 10.1038/s41594-024-01228-3

実験手法

ELECTRON MICROSCOPY (2.34 Å)