8FPL

LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg)

Summary for 8FPL

Entry DOI	10.2210/pdb8fpl/pdb
EMDB information	29360 29361 29363 29364 29367 29368
Descriptor	Glutamate receptor 2, 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione, CYCLOTHIAZIDE (3 entities in total)
Functional Keywords	ionotropic glutamate receptors, ampa receptors, ion channel, ligand-gated ion channel, auxiliary subunit, stargazing, tarp gamma2, transport protein
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	4
Total formula weight	400742.09
Authors	Nakagawa, T. (deposition date: 2023-01-04, release date: 2024-02-28, Last modification date: 2024-05-01)
Primary citation	Nakagawa, T.,Wang, X.T.,Miguez-Cabello, F.J.,Bowie, D. The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31:688-700, 2024 Cited by PubMed: 38409505 DOI: 10.1038/s41594-024-01228-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.81 Å)

Structure validation