8FPE

Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog T0-BP

8FPE の概要

• エントリーDOI: 10.2210/pdb8fpe/pdb
• 分子名称: Nuclear receptor subfamily 1 group I member 2, N-[([1,1'-biphenyl]-4-yl)methyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzenesulfonamide (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, metabolism, antibiotic, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36774.27

構造登録者

Huber, A.D.,Poudel, S.,Seetharaman, J.,Miller, D.J.,Lin, W.,Li, Y.,Chen, T. (登録日: 2023-01-04, 公開日: 2023-03-15, 最終更新日: 2024-05-22)

• 主引用文献: Lin, W.,Huber, A.D.,Poudel, S.,Li, Y.,Seetharaman, J.,Miller, D.J.,Chen, T.; Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.; Proc.Natl.Acad.Sci.USA, 120:e2217804120-e2217804120, 2023; PubMed: 36848571; DOI: 10.1073/pnas.2217804120

実験手法

X-RAY DIFFRACTION (2.3 Å)