8FOW
Ternary complex of CDK2 with small molecule ligands TW8672 and Dinaciclib
Summary for 8FOW
Entry DOI | 10.2210/pdb8fow/pdb |
Descriptor | Cyclin-dependent kinase 2, 1,2-ETHANEDIOL, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... (5 entities in total) |
Functional Keywords | allosteric, inhibitor, cell cycle, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34823.44 |
Authors | Schonbrunn, E.,Sun, L. (deposition date: 2023-01-03, release date: 2023-05-31, Last modification date: 2023-10-25) |
Primary citation | Faber, E.B.,Sun, L.,Tang, J.,Roberts, E.,Ganeshkumar, S.,Wang, N.,Rasmussen, D.,Majumdar, A.,Hirsch, L.E.,John, K.,Yang, A.,Khalid, H.,Hawkinson, J.E.,Levinson, N.M.,Chennathukuzhi, V.,Harki, D.A.,Schonbrunn, E.,Georg, G.I. Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14:3213-3213, 2023 Cited by PubMed: 37270540DOI: 10.1038/s41467-023-38732-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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