8FOB

Cryo-EM structure of human TRPV6 in the open state

Summary for 8FOB

Entry DOI	10.2210/pdb8fob/pdb
Related	8FOA
EMDB information	29343 29344
Descriptor	Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total)
Functional Keywords	transient receptor potential v family member 6, trp, human, channel, apo state, open, trpv6, trp channels, cancer, oncochannel, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	363562.79
Authors	Neuberger, A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2022-12-30, release date: 2023-05-24, Last modification date: 2024-06-19)
Primary citation	Neuberger, A.,Trofimov, Y.A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Krylov, N.A.,Efremov, R.G.,Sobolevsky, A.I. Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14:2659-2659, 2023 Cited by PubMed: 37160865 DOI: 10.1038/s41467-023-38352-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.71 Å)

Structure validation