8FOB

Cryo-EM structure of human TRPV6 in the open state

8FOB の概要

• エントリーDOI: 10.2210/pdb8fob/pdb
• 関連するPDBエントリー: 8FOA
• EMDBエントリー: 29343 29344
• 分子名称: Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (6 entities in total)
• 機能のキーワード: transient receptor potential v family member 6, trp, human, channel, apo state, open, trpv6, trp channels, cancer, oncochannel, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 363562.79

構造登録者

Neuberger, A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Sobolevsky, A.I. (登録日: 2022-12-30, 公開日: 2023-05-24, 最終更新日: 2024-06-19)

• 主引用文献: Neuberger, A.,Trofimov, Y.A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Krylov, N.A.,Efremov, R.G.,Sobolevsky, A.I.; Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein.; Nat Commun, 14:2659-2659, 2023; PubMed: 37160865; DOI: 10.1038/s41467-023-38352-5

実験手法

ELECTRON MICROSCOPY (2.71 Å)