8FO3

Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with (E)-3-nitro-4-(2-(2-phenylpropylidene)hydrazineyl)benzenesulfonamide

8FO3 の概要

• エントリーDOI: 10.2210/pdb8fo3/pdb
• 分子名称: H9 immunoglobulin light chain, 3-nitro-4-{2-[(2S)-2-phenylpropyl]hydrazin-1-yl}benzene-1-sulfonamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: light chain, amyloidosis, stabilizer, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 273268.08

構造登録者

Yan, N.L.,Wilson, I.A.,Kelly, J.W. (登録日: 2022-12-29, 公開日: 2023-05-24, 最終更新日: 2026-04-15)

• 主引用文献: Yan, N.L.,Wilson, I.A.,Kelly, J.W.; Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand-Binding Cavity; Isr.J.Chem., 2023; DOI: 10.1002/ijch.202300002

実験手法

X-RAY DIFFRACTION (2 Å)