8FLY
HIV-1 gp120 complex with BNM-III-170
Summary for 8FLY
Entry DOI | 10.2210/pdb8fly/pdb |
Descriptor | Envelope glycoprotein gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-5-(methylaminomethyl)-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide, ... (4 entities in total) |
Functional Keywords | retrovirus, gp120, entry inhibitor, structure-based drug design, small molecule, antiretroviral therapy, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | HIV-1 06TG.HT008 |
Total number of polymer chains | 4 |
Total formula weight | 166561.69 |
Authors | |
Primary citation | Fritschi, C.J.,Anang, S.,Gong, Z.,Mohammadi, M.,Richard, J.,Bourassa, C.,Severino, K.T.,Richter, H.,Yang, D.,Chen, H.C.,Chiu, T.J.,Seaman, M.S.,Madani, N.,Abrams, C.,Finzi, A.,Hendrickson, W.A.,Sodroski, J.G.,Smith III, A.B. Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc.Natl.Acad.Sci.USA, 120:e2222073120-e2222073120, 2023 Cited by PubMed: 36961924DOI: 10.1073/pnas.2222073120 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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