8FLW

Cryo-EM Structure of PGT145 DU303 Fab in complex with BG505 DS-SOSIP.664

Summary for 8FLW

Entry DOI	10.2210/pdb8flw/pdb
EMDB information	29288
Descriptor	PGT145 DU303 Heavy, PGT145 DU303 Light, Envelope glycoprotein gp41, ... (8 entities in total)
Functional Keywords	cd4, hiv-1, sosip, vaccine, immune system, llama, v2 apex, therapeutic, viral protein
Biological source	Homo sapiens More
Total number of polymer chains	8
Total formula weight	285871.07
Authors	Gorman, J.,Kwong, P.D. (deposition date: 2022-12-22, release date: 2023-05-31, Last modification date: 2023-07-26)
Primary citation	Holt, G.T.,Gorman, J.,Wang, S.,Lowegard, A.U.,Zhang, B.,Liu, T.,Lin, B.C.,Louder, M.K.,Frenkel, M.S.,McKee, K.,O'Dell, S.,Rawi, R.,Shen, C.H.,Doria-Rose, N.A.,Kwong, P.D.,Donald, B.R. Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design. Cell Rep, 42:112711-112711, 2023 Cited by PubMed: 37436900 DOI: 10.1016/j.celrep.2023.112711 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.58 Å)

Structure validation