8FJW
Human GAR transformylase in complex with GAR substrate and AGF347 inhibitor
8FJW の概要
エントリーDOI | 10.2210/pdb8fjw/pdb |
分子名称 | Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-glutamic acid, ... (4 entities in total) |
機能のキーワード | garftase, purine biosynthesis, monomer, inhibitor, ligase, ligase-inhibitor complex, ligase/inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 23567.75 |
構造登録者 | |
主引用文献 | Nayeen, M.J.,Katinas, J.M.,Magdum, T.,Shah, K.,Wong, J.E.,O'Connor, C.E.,Fifer, A.N.,Wallace-Povirk, A.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A. Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. J.Med.Chem., 66:11294-11323, 2023 Cited by PubMed: 37582241DOI: 10.1021/acs.jmedchem.3c00763 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.08 Å) |
構造検証レポート
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