8FIG

Room-temperature X-ray structure of SARS-CoV-2 main protease double mutant E290A/R298A in complex with GC373

8FIG の概要

• エントリーDOI: 10.2210/pdb8fig/pdb
• 分子名称: 3C-like proteinase nsp5, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (3 entities in total)
• 機能のキーワード: cysteine protease, homodimer, double mutant, hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34086.88

構造登録者

Kovalevsky, A.,Coates, L.,Kneller, D.W. (登録日: 2022-12-16, 公開日: 2023-11-22)

• 主引用文献: Aniana, A.,Nashed, N.T.,Ghirlando, R.,Coates, L.,Kneller, D.W.,Kovalevsky, A.,Louis, J.M.; Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors.; Commun Biol, 6:1159-1159, 2023; PubMed: 37957287; DOI: 10.1038/s42003-023-05469-8

実験手法

X-RAY DIFFRACTION (1.75 Å)