8FI9

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody WRAIR-5001

8FI9 の概要

• エントリーDOI: 10.2210/pdb8fi9/pdb
• 分子名称: Spike protein S1, WRAIR-5001 Fab Light chain, WRAIR-5001 Fab Heavy chain, ... (6 entities in total)
• 機能のキーワード: viral protein, sars-cov-2, coronavirus, immune system, antibody, nonhuman primate, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 2019-nCoV, COVID-19 virus); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 282462.01

構造登録者

Sankhala, R.S.,Jensen, J.L.,Joyce, M.G. (登録日: 2022-12-15, 公開日: 2024-01-17)

• 主引用文献: Sankhala, R.S.,Lal, K.G.,Jensen, J.L.,Dussupt, V.,Mendez-Rivera, L.,Bai, H.,Wieczorek, L.,Mayer, S.V.,Zemil, M.,Wagner, D.A.,Townsley, S.M.,Hajduczki, A.,Chang, W.C.,Chen, W.H.,Donofrio, G.C.,Jian, N.,King, H.A.D.,Lorang, C.G.,Martinez, E.J.,Rees, P.A.,Peterson, C.E.,Schmidt, F.,Hart, T.J.,Duso, D.K.,Kummer, L.W.,Casey, S.P.,Williams, J.K.,Kannan, S.,Slike, B.M.,Smith, L.,Swafford, I.,Thomas, P.V.,Tran, U.,Currier, J.R.,Bolton, D.L.,Davidson, E.,Doranz, B.J.,Hatziioannou, T.,Bieniasz, P.D.,Paquin-Proulx, D.,Reiley, W.W.,Rolland, M.,Sullivan, N.J.,Vasan, S.,Collins, N.D.,Modjarrad, K.,Gromowski, G.D.,Polonis, V.R.,Michael, N.L.,Krebs, S.J.,Joyce, M.G.; Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques.; Nat Commun, 15:200-200, 2024; PubMed: 38172512; DOI: 10.1038/s41467-023-44265-0

実験手法

X-RAY DIFFRACTION (4.2 Å)