8FFU

Structure of GntC, a PLP-dependent enzyme catalyzing L-enduracididine biosynthesis from (S)-4-hydroxy-L-arginine, with the substrate bound

8FFU の概要

• エントリーDOI: 10.2210/pdb8ffu/pdb
• 関連するPDBエントリー: 8FFT
• 分子名称: Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, MAGNESIUM ION, (2S,4S)-5-carbamimidamido-4-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pentanoic acid (non-preferred name), ... (5 entities in total)
• 機能のキーワード: plp, gntc, cyclodehydration, (s)-4-hydroxy-l-arginine, guanitoxin, l-enduracididine, cyanobacterial blooms, biocatalysis, biosynthesis, cyanobacterium, biosynthetic protein
• 由来する生物種: Dolichospermum flos-aquae; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 167942.38

構造登録者

Chen, P.Y.-T.,Moore, B.S. (登録日: 2022-12-10, 公開日: 2023-04-12, 最終更新日: 2023-11-15)

• 主引用文献: Cordoza, J.L.,Chen, P.Y.,Blaustein, L.R.,Lima, S.T.,Fiore, M.F.,Chekan, J.R.,Moore, B.S.,McKinnie, S.M.K.; Mechanistic and Structural Insights into a Divergent PLP-Dependent l-Enduracididine Cyclase from a Toxic Cyanobacterium.; Acs Catalysis, 13:9817-9828, 2023; PubMed: 37497377; DOI: 10.1021/acscatal.3c01294

実験手法

X-RAY DIFFRACTION (2.04 Å)