8FE9
Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b
Summary for 8FE9
| Entry DOI | 10.2210/pdb8fe9/pdb |
| Descriptor | Activated CDC42 kinase 1, N-[(1S)-1-benzyl-2-[(6-chloro-2-oxo-1H-quinolin-4-yl)methylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carbo (3 entities in total) |
| Functional Keywords | tyrosine kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 32980.31 |
| Authors | Paung, Y.,Kan, Y.,Seeliger, M.S.,Miller, W.T. (deposition date: 2022-12-06, release date: 2023-03-29) |
| Primary citation | Kan, Y.,Paung, Y.,Kim, Y.,Seeliger, M.A.,Miller, W.T. Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk. Biochemistry, 62:1124-1137, 2023 Cited by PubMed: 36854171DOI: 10.1021/acs.biochem.2c00685 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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