8FE9

Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b

8FE9 の概要

• エントリーDOI: 10.2210/pdb8fe9/pdb
• 分子名称: Activated CDC42 kinase 1, N-[(1S)-1-benzyl-2-[(6-chloro-2-oxo-1H-quinolin-4-yl)methylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carbo (3 entities in total)
• 機能のキーワード: tyrosine kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32980.31

構造登録者

Paung, Y.,Kan, Y.,Seeliger, M.S.,Miller, W.T. (登録日: 2022-12-06, 公開日: 2023-03-29)

• 主引用文献: Kan, Y.,Paung, Y.,Kim, Y.,Seeliger, M.A.,Miller, W.T.; Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.; Biochemistry, 62:1124-1137, 2023; PubMed: 36854171; DOI: 10.1021/acs.biochem.2c00685

実験手法

X-RAY DIFFRACTION (3.2 Å)