8FE2
Structure of J-PKAc chimera complexed with Aplithianine A
8FE2 の概要
エントリーDOI | 10.2210/pdb8fe2/pdb |
分子名称 | DnaJ homolog subfamily B member 1, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 6-[(6M)-6-(1-methyl-1H-imidazol-5-yl)-2,3-dihydro-4H-1,4-thiazin-4-yl]-9H-purine, ... (4 entities in total) |
機能のキーワード | protein kinase a, fibrolamellar hepatocellular carcinoma, natural product, signaling protein |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 100235.42 |
構造登録者 | Du, L.,Wilson, B.A.P.,Li, N.,Dalilian, M.,Wang, D.,Martinez Fiesco, J.A.,Smith, E.A.,Wamiru, A.,Goncharova, E.I.,Zhang, P.,O'Keefe, B.R. (登録日: 2022-12-05, 公開日: 2023-10-18, 最終更新日: 2024-05-01) |
主引用文献 | Du, L.,Wilson, B.A.P.,Li, N.,Shah, R.,Dalilian, M.,Wang, D.,Smith, E.A.,Wamiru, A.,Goncharova, E.I.,Zhang, P.,O'Keefe, B.R. Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J.Nat.Prod., 86:2283-2293, 2023 Cited by PubMed: 37843072DOI: 10.1021/acs.jnatprod.3c00394 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.34 Å) |
構造検証レポート
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