8FDX

AGF271 and GAR in complex with human recombinant GARFTase, ligase, purine biosynthesis, transfers formyl group from 10-formyl tetrahydrofolate to glycinamide ribonucleotide (GAR) to form tetrahydrofolate and formyl GAR

8FDX の概要

• エントリーDOI: 10.2210/pdb8fdx/pdb
• 分子名称: Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[3-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)propyl]thiophene-2-carbonyl}-L-glutamic acid, ... (4 entities in total)
• 機能のキーワード: garftase, ligase, purine biosynthesis, monomer
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23558.81

構造登録者

Nyman, M.C.,Wong-Roushar, J.,Dann III, C.E. (登録日: 2022-12-05, 公開日: 2023-05-10, 最終更新日: 2023-10-25)

• 主引用文献: Tong, N.,Wong-Roushar, J.,Wallace-Povirk, A.,Shah, Y.,Nyman, M.C.,Katinas, J.M.,Schneider, M.,O'Connor, C.,Bao, X.,Kim, S.,Li, J.,Hou, Z.,Matherly, L.H.,Dann 3rd, C.E.,Gangjee, A.; Multitargeted 6-Substituted Thieno[2,3- d ]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.; Acs Pharmacol Transl Sci, 6:748-770, 2023; PubMed: 37200803; DOI: 10.1021/acsptsci.3c00020

実験手法

X-RAY DIFFRACTION (2.07 Å)