8FDU

Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1)

8FDU の概要

• エントリーDOI: 10.2210/pdb8fdu/pdb
• EMDBエントリー: 29012 29014
• 分子名称: Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, Platelet-activating factor acetylhydrolase IB subunit beta,Platelet-activating factor acetylhydrolase IB subunit beta,human LIS1 protein with a SNAP tag, ADENOSINE-5'-DIPHOSPHATE (3 entities in total)
• 機能のキーワード: dynein, motor domain, microtubule-unbound, motor protein, lis1
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 491160.62

構造登録者

Ton, W.,Wang, Y.,Chai, P. (登録日: 2022-12-04, 公開日: 2023-06-21, 最終更新日: 2023-11-15)

• 主引用文献: Ton, W.D.,Wang, Y.,Chai, P.,Beauchamp-Perez, C.,Flint, N.T.,Lammers, L.G.,Xiong, H.,Zhang, K.,Markus, S.M.; Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport.; Nat.Struct.Mol.Biol., 30:1365-1379, 2023; PubMed: 37322240; DOI: 10.1038/s41594-023-01010-x

実験手法

ELECTRON MICROSCOPY (3.3 Å)