8FD9

Structure of BTK kinase domain with the second-generation inhibitor acalabrutinib

8FD9 の概要

• エントリーDOI: 10.2210/pdb8fd9/pdb
• 分子名称: Tyrosine-protein kinase BTK, 4-[(4S)-8-amino-3-{(2S)-1-[(2E)-but-2-enoyl]pyrrolidin-2-yl}imidazo[1,5-a]pyrazin-1-yl]-N-(pyridin-2-yl)benzamide, BROMIDE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, kinase, complex, covalent, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32608.66

構造登録者

Lin, D.Y.,Andreotti, A.H. (登録日: 2022-12-02, 公開日: 2023-07-05, 最終更新日: 2023-09-13)

• 主引用文献: Lin, D.Y.,Andreotti, A.H.; Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib.; Plos One, 18:e0290872-e0290872, 2023; PubMed: 37651403; DOI: 10.1371/journal.pone.0290872

実験手法

X-RAY DIFFRACTION (1.7 Å)