8FCC
HIV-1 Reverse Transcriptase in complex with 5-membered bicyclic core NNRTI
Summary for 8FCC
Entry DOI | 10.2210/pdb8fcc/pdb |
Descriptor | p66 RT, p51 RT, 4-[(9-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}-8-oxo-8,9-dihydro-7H-purin-2-yl)amino]benzonitrile, ... (5 entities in total) |
Functional Keywords | hiv-1, reverse transcriptase, inhibitor, antiviral, viral protein |
Biological source | HIV whole-genome vector AA1305#18 More |
Total number of polymer chains | 2 |
Total formula weight | 116519.51 |
Authors | Lansdon, E.B. (deposition date: 2022-12-01, release date: 2023-02-01, Last modification date: 2024-05-22) |
Primary citation | Prener, L.,Baszczynski, O.,Kaiser, M.M.,Dracinsky, M.,Stepan, G.,Lee, Y.J.,Brumshtein, B.,Yu, H.,Jansa, P.,Lansdon, E.B.,Janeba, Z. Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties. J.Med.Chem., 66:1761-1777, 2023 Cited by PubMed: 36652602DOI: 10.1021/acs.jmedchem.2c01574 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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