8FBQ
Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b
Summary for 8FBQ
Entry DOI | 10.2210/pdb8fbq/pdb |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... (12 entities in total) |
Functional Keywords | enzyme, inhibitor, complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Plasmodium vivax |
Total number of polymer chains | 1 |
Total formula weight | 48454.53 |
Authors | Fenwick, M.K.,Staker, B.L.,Lovell, S.W.,Phan, I.Q.,Early, J.,Myler, P.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-11-29, release date: 2023-10-18) |
Primary citation | Rodriguez-Hernandez, D.,Vijayan, K.,Zigweid, R.,Fenwick, M.K.,Sankaran, B.,Roobsoong, W.,Sattabongkot, J.,Glennon, E.K.K.,Myler, P.J.,Sunnerhagen, P.,Staker, B.L.,Kaushansky, A.,Grotli, M. Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts. Nat Commun, 14:5408-5408, 2023 Cited by PubMed: 37669940DOI: 10.1038/s41467-023-41119-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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