8FBQ

Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b

8FBQ の概要

• エントリーDOI: 10.2210/pdb8fbq/pdb
• 分子名称: Glycylpeptide N-tetradecanoyltransferase, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... (12 entities in total)
• 機能のキーワード: enzyme, inhibitor, complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48454.53

構造登録者

Fenwick, M.K.,Staker, B.L.,Lovell, S.W.,Phan, I.Q.,Early, J.,Myler, P.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2022-11-29, 公開日: 2023-10-18)

• 主引用文献: Rodriguez-Hernandez, D.,Vijayan, K.,Zigweid, R.,Fenwick, M.K.,Sankaran, B.,Roobsoong, W.,Sattabongkot, J.,Glennon, E.K.K.,Myler, P.J.,Sunnerhagen, P.,Staker, B.L.,Kaushansky, A.,Grotli, M.; Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.; Nat Commun, 14:5408-5408, 2023; PubMed: 37669940; DOI: 10.1038/s41467-023-41119-7

実験手法

X-RAY DIFFRACTION (1.65 Å)