8F9Z

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-14204, an HIV-1 gp120 antagonist

8F9Z の概要

• エントリーDOI: 10.2210/pdb8f9z/pdb
• 分子名称: HIV-1 gp120 core, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5M)-N-{(1S)-2-amino-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl}-5-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: hiv-1, nbd-14204, small molecules, cd4-gp120 binding inhibitor, antagonist, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41137.32

構造登録者

Kwon, Y.D.,Kwong, P.D. (登録日: 2022-11-25, 公開日: 2023-01-11, 最終更新日: 2023-09-20)

• 主引用文献: Curreli, F.,Kwon, Y.D.,Nicolau, I.,Burgos, G.,Altieri, A.,Kurkin, A.V.,Verardi, R.,Kwong, P.D.,Debnath, A.K.; Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists.; Int J Mol Sci, 23:-, 2022; PubMed: 36555641; DOI: 10.3390/ijms232415999

実験手法

X-RAY DIFFRACTION (1.94 Å)