8F7P

BRAF kinase in complex with LXH254 (naporafenib)

Summary for 8F7P

Entry DOI	10.2210/pdb8f7p/pdb
Descriptor	Serine/threonine-protein kinase B-raf, N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide (3 entities in total)
Functional Keywords	braf, lxh254, naporafenib, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	65034.34
Authors	Tkacik, E.,Li, K.,Gonzalez Del-Pino, G.,Eck, M.J. (deposition date: 2022-11-20, release date: 2023-04-12, Last modification date: 2024-05-22)
Primary citation	Tkacik, E.,Li, K.,Gonzalez-Del Pino, G.,Ha, B.H.,Vinals, J.,Park, E.,Beyett, T.S.,Eck, M.J. Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib. J.Biol.Chem., 299:104634-104634, 2023 Cited by PubMed: 36963492 DOI: 10.1016/j.jbc.2023.104634 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.74 Å)

Structure validation