8F7P

BRAF kinase in complex with LXH254 (naporafenib)

8F7P の概要

• エントリーDOI: 10.2210/pdb8f7p/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide (3 entities in total)
• 機能のキーワード: braf, lxh254, naporafenib, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65034.34

構造登録者

Tkacik, E.,Li, K.,Gonzalez Del-Pino, G.,Eck, M.J. (登録日: 2022-11-20, 公開日: 2023-04-12, 最終更新日: 2024-05-22)

• 主引用文献: Tkacik, E.,Li, K.,Gonzalez-Del Pino, G.,Ha, B.H.,Vinals, J.,Park, E.,Beyett, T.S.,Eck, M.J.; Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib.; J.Biol.Chem., 299:104634-104634, 2023; PubMed: 36963492; DOI: 10.1016/j.jbc.2023.104634

実験手法

X-RAY DIFFRACTION (2.74 Å)