8F7O
BRAF kinase in complex with TAK580 (tovorafenib)
Summary for 8F7O
| Entry DOI | 10.2210/pdb8f7o/pdb |
| Descriptor | Serine/threonine-protein kinase B-raf, 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide (2 entities in total) |
| Functional Keywords | braf, tak580, tovorafenib, transferase, transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 65041.94 |
| Authors | Tkacik, E.,Li, K.,Gonzalez Del-Pino, G.,Eck, M.J. (deposition date: 2022-11-20, release date: 2023-04-12, Last modification date: 2024-05-22) |
| Primary citation | Tkacik, E.,Li, K.,Gonzalez-Del Pino, G.,Ha, B.H.,Vinals, J.,Park, E.,Beyett, T.S.,Eck, M.J. Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib. J.Biol.Chem., 299:104634-104634, 2023 Cited by PubMed: 36963492DOI: 10.1016/j.jbc.2023.104634 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.54 Å) |
Structure validation
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