8F7O

BRAF kinase in complex with TAK580 (tovorafenib)

8F7O の概要

• エントリーDOI: 10.2210/pdb8f7o/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide (2 entities in total)
• 機能のキーワード: braf, tak580, tovorafenib, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65041.94

構造登録者

Tkacik, E.,Li, K.,Gonzalez Del-Pino, G.,Eck, M.J. (登録日: 2022-11-20, 公開日: 2023-04-12, 最終更新日: 2024-05-22)

• 主引用文献: Tkacik, E.,Li, K.,Gonzalez-Del Pino, G.,Ha, B.H.,Vinals, J.,Park, E.,Beyett, T.S.,Eck, M.J.; Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib.; J.Biol.Chem., 299:104634-104634, 2023; PubMed: 36963492; DOI: 10.1016/j.jbc.2023.104634

実験手法

X-RAY DIFFRACTION (3.54 Å)